Medol is a food supplement indicated for women based on extracts of chasteberry, angelica, feverfew, magnesium and vitamin B6. The chasteberry, angelica and feverfew help to counteract the disorders of the menstrual cycle. Magnesium contributes to the reduction of tiredness and fatigue and to normal psychological function. Vitamin B6 contributes to the normal formation of red blood cells, the regulation of hormonal activity and the normal functioning of the nervous system.Many women suffer from annoying disorders, often even limiting ones, in the days preceding the menstrual cycle, the PMS, premenstrual syndrome. These disorders manifest themselves with complex symptomatology, in some cases with very acute and disabling forms even for a few days. PMS is felt about 7-10 days before the onset of menstruation, with pain and tension in the breast, frequent headache, irritability with marked mood drops, increased anxiety, greater tiredness, swelling of the abdomen and lower limbs, pimples, tendency to seek sweet and greasy food.All this complex of PMS symptoms has not been attributed to a univocal cause as it is thought that there are several factors that act synergistically.Hormonal changes during the menstrual cycle seem to be an important cause, but there may also be in place some neurotransmitters imbalances (see dopamine and serotonin) capable of influencing stress levels and mood swings, even causing a slight form of depression. Although hormones and neurotransmitters imbalances don t seem to cause the syndrome, they can surely emphasize it.Scientific data attribute to the magnesium deficiency the responsibility of symptoms such as headache, muscle cramps, and uterus pain due to an increase in hormones that regulate the balance of mineral salts in our body. In regard to hormonal imbalances, an increase in the level of estrogen and prolactin is also thought to be the basis of the increase of breast volume and water retention that causes weight gain and constipation.The fact is that many women in these particular days suffer from all (or part of) these psychophysical symptoms lead to more or less debilitating conditions.In this regard, nutraceuticals have been shown to have some interesting and effective weapons to prevent or alleviate, at least in part, these nuisances.The chasteberry (Vitex Agnus Castus L.) is also called the chaste tree or tree of chastity because, in the Middle Ages, it was used by monks to inhibit libido in monasteries thanks to its anti-aphrodisiac qualities.Several studies have shown the beneficial effect of chasteberry on all the premenstrual syndrome symptoms and the remedy has become a commonly recommended supplement for many gynecologists. The German Ministry of Health has already approved its use for irregularities in the menstrual cycle, premenstrual syndrome and mastodynia (breast pain that worsens in the premenstrual phase). The parts used in natural supplements are dried fruits, rich in flavonoids, glycosides, and terpenes.Chasteberry appears to have a direct action on the female endocrine system, especially on the pituitary gland, where the release of prolactin and the balance between estrogen and progesterone occur. The benefits following chasteberry intake are then manifested by the reduction of breast tension, better regulation of menstrual flow, but also flushes control, which makes it great in menopause. In most cases, estrogen predominates at the expense of progesterone, and this leads to ailments that include irritability, sensitive and painful breasts, water retention and uterine pain, but also abundant menstruation, infertility, weight gain, cellulite, migraines, food compulsion or acne. The chasteberry acts directly on female hormones, estrogen, and progesterone, positively influencing the menstrual cycle, improving fertility, and mood. It also acts on the production of dopamine and prolactin which influence the secretion of progesterone.Another useful phytoextract for premenstrual syndrome is angelica (Angelica Sinensis) used in traditional Chinese medicine to support the female apparatus and soothe menstrual disorders, such as amenorrhea, dysmenorrhea, and unbalanced menopausal conditions. The part used in natural supplements for premenstrual syndrome is the angelica root, which contains ferulic acid, vitamins B12, A and E, ascorbic acid, phytosterols, and mineral salts. Angelica smooths and relaxes muscles, in particular, it has an antispasmodic action on uterine contractures, reducing those cramps and spasms characterizing dysmenorrhea (i.e. painful menstruation) and has anti-inflammatory for the female apparatus. The Chinese tradition suggests that angelica is also used to relieve menopause s hot flashes and sweating. Angelica generally helps to rebalance the female hormonal structure as a whole, which is how we can partially explain the benefits of all gynecological symptoms.Another valuable ally that women can rely on to counteract PMS symptoms is magnesium. During the 7-10 days of the luteal phase that lead to fluctuations in estrogen and progesterone with neurotransmitter imbalances, a vast series of emotional, physical and behavioral symptoms. Although science is still trying to find out precisely the mechanisms underlying PMS, it has emerged in different studies that magnesium deficiency during the luteal phase is an influencing factor, especially for symptoms such as migraine, cramps, irritability, and moodiness. The administration of magnesium has shown, for the majority of patients involved in the studies, a significant decrease in pain and irritability.In modern herbal medicine, feverfew is used to prevent migraine and headache crises, but its beneficial effect has been rediscovered for PMS and cycle pain. Its active ingredient is parthenolide, an analgesic that relaxes blood vessels muscles and prevents the release of serotonin, the triggering cause of migraine. This can certainly favor women who suffer from it during those days , in particular, its antispasmodic effect is recommended to attenuate cycle pain. As with other previous natural substances, feverfew lends itself as a valuable and synergistic aid for women, taken at least seven to ten days before the period.Vitamin B6 (pyridoxine) is often present in all PMS supplements, and it is called woman s vitamin because it is able to relieve breast pain and headache, decreasing water retention as well as mood swings, since it is involved in the serotonin synthesis process. Furthermore, among its functions, there is that of maintaining hormonal balance by increasing the progesterone production and the demolition of estrogen by the liver. It also increases the threshold of pain perception.